Santo Spirito Vacations from $994

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Your Santo Spirito Vacation

Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.

The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $1,353, price is now $994 per person
$994
per person
Feb 5 - Feb 10
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
7.4/10 Good! (1,016 reviews)
Nice place, good location

Reviewed on Nov 11, 2026

Donati Luxury Tower Suites

Donati Luxury Tower Suites

5 out of 5
Historic Centre of Florence
Price was $2,754, price is now $1,915 per person
$1,915
per person
Feb 5 - Feb 10
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.8/10 Exceptional! (82 reviews)
Great boutique hotel with good size room and bathroom. Very clean and helpful staff. Would definitely stay here again.

Reviewed on Nov 9, 2026

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Price was $1,480, price is now $1,039 per person
$1,039
per person
Feb 5 - Feb 10
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
7.6/10 Good! (1,003 reviews)

Hotel Duomo Firenze

Hotel Duomo Firenze

3 out of 5
Historic Centre of Florence
Price was $4,413, price is now $3,147 per person
$3,147
per person
Dec 28 - Jan 2
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.2/10 Wonderful! (1,003 reviews)
Amazing location. So cool to be literally across from the Duomo. Easy walk to so many places to shop and eat. Free sparkling and still water was great. Snacks and free gelato! Staff was the most friendly and helpful. Highly recommend this place!

Reviewed on Nov 3, 2026

Palazzo Monnalisa

Palazzo Monnalisa

5 out of 5
Historic Centre of Florence
Price was $2,136, price is now $1,602 per person
$1,602
per person
Feb 5 - Feb 10
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9/10 Wonderful! (810 reviews)

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Find hotels in Historic Centre of Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundable
$124 nightly
The price is $152 total per night from Dec 8 to Dec 9
$152 total
Dec 8 - Dec 9
Total with taxes and fees
Hotel Horto Convento
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $98 total per night from Nov 15 to Nov 16
$98 total
Nov 15 - Nov 16
Total with taxes and fees
8.4/10 Very Good! (1,001 reviews)
"Conveniently located, easy parking, extremely friendly staff, delicious breakfast, quirky rooms."

Reviewed on Oct 27, 2026

UNA Hotels Vittoria Firenze
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $144 total per night from Dec 3 to Dec 4
$144 total
Dec 3 - Dec 4
Total with taxes and fees
Palazzo Mannaioni Suites
See all 520 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
See properties

Things to do

Picture 1 for Activity Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

$20
per adult
94% of travellers recommend
Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine
City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$26
per adult
74% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

$44
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.